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There are different types of thermogenic fat burners. Most of them will try to boost your metabolism by using many kinds of combined ingredients., some of it can be loaded with harmful ingredients. Many use caffeine in relatively high doses to accomplish some kind of metabolic increase, but come with many harmful side effects. These include jittery nerves, inability to sleep, anxiety, and constricted vessels (not to mention addiction). Constricted vessels are particularly damaging because they inhibit your body from receiving the benefits of the ingredients in the supplement. Try to avoid the type of thermogenic fat burners that rely on lots of caffeine.